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Smart Freeze Drying - Martin Christ

Contents 1 Introduction 4 2 Basic principles 6 3 Freeze Dryer Design 8 4 Procedures 10 4.1 Overview 10 4.2 Freezing 12 4.3 Primary drying and secondary drying 16 5 Practical aspects 24 5.1 Warm up / Cool down 24 5.2 Shell-Freezing and Spin-Freezing 24 5.3 Achievable vacuum values 25 5.4 Determining the end of drying / PAT 26

Use of manometric temperature measurement (MTM) and SMART ...

Dec 01, 2007 The commercial SMART™ Freeze Dryer technology was developed for a new laboratory scale freeze dryer (Lyostar II) which is different in size and geometry from the initially tested smaller unit (Durastop). Here, for the Lyostar II, the “effective gas volume” for a pressure rise test is determined to be 107.5 L as reported above.

Optimization of Primary Drying Time Using a Combination of ...

Dec 18, 2013 SP Scientific’s Lyostar 3 development freeze dryer incorporates a technology called SMART™ freeze-drying. SMART™ was developed by the University of Connecticut and Purdue University through the Center for Pharmaceutical Processing Research (CPPR) and licensed to SP [1].

3 DIY Freeze Dryers You Can Make at Home

Feb 01, 2022 Whatever you intend to use your freeze dryer for, building your own DIY freeze dryer can save you a significant amount of money. 1. Easy Home Freeze Dryer. You might have heard about astronaut ice cream; it's one of the most famous examples of freeze-dried food. Developed for space travel, astronaut ice cream is real ice cream that has had all ...

SMART Freeze Dryer Technology Optimizes Cycle Development

For further information on SMART Freeze Dryer technology please contact SP Scientific on +1-845-255-5000 or email [email protected] SP Scientific is a leading manufacturer of laboratory to production scale freeze dryers / lyophilizers, centrifugal evaporators and concentrators, thermal control system and glassware washers.

Key Technologies Science meets Innovation - GILYOS GmbH

Friedrich-Bergius-Ring 15 D-97076 Wuerzburg Germany Phone: +49 931 90705678 Fax: +49 931 90705679 [email protected] Follow GILYOS on

Freeze Dryer Overview - SP Scientific Products - PDF ...

Genesis Pilot Lyophilizers for Product Development and Small Batch Production Expertly designed with your needs in mind • Space saving, self-contained mobile tray freeze dryer • Available as a stand-alone or clean room configuration • One to six shelf (bulk) or 5 shelf (stoppering) capacity offering 1.5 ft2/. 14m2 • Large capacity pilot scale with condenser choice …

PAT Advances Freeze Dryer Control

Jul 01, 2004 FTS Systems (Stone Ridge, N.Y.) has licensed the technology from Purdue and the University of Connecticut and is now incorporating it into freeze drying equipment. The Smart Freeze Dryer algorithms use manometric pressure, first described in 1997 by Purdue professor Steve Nail, who now works for Eli Lilly, to determine temperature, mass ...

Freeze Dryers Lyophilizers Millrock Technology Inc

Millrock Technology is an innovator in advanced freeze dryer technology for pharmaceutical, biotechnology, diagnostics, and life science applications. The Trademarked and Registered Products on this website are the intellectual property of Millrock Technology, Inc. Patent and Patent Pending Technologies applied for.

Life Sciences Freeze Dryer - Millrock Technology Inc

Millrock's freeze dryers / lyophilizers for the life sciences have been developed with over 50 years of experience in the freeze drying world. Our designs provide a highly reliable platform for your needs. Advanced system options include FreezeBooster Controlled Nucleation, Auto-Dry™ Protocol Optimizat ion, AccuFlux Heat Flow Measurement and LyoPAT In-Process, …

PAT for freeze drying:cycle optimisation in the laboratory

MTM and SMART Freeze Dryer technology is shown in Figure 1 (page 63).A freeze drying cycle was performed for a 100 mg/mL sucrose sample solution (20 mL tubing vials, 3 mL total fill volume) and a known collapse temperature of - 32C6.The SMART Freeze Dryer software automatically elevated the shelf temperature in two steps to -20C

News Release November 7 2007 - SP Industries

Nov 07, 2007 SMART Freeze-Dryer Technology is the result of a development partnership and an exclusive licensing agreement with the University of Connecticut (UConn) and Purdue University. For more information, please contact Leslie Mather, 845-687-5315, email: [email protected] , or visit our web site at www.FTSsystems.com .

Product Technologies for Lyophilization

Nov 15, 2006 “Smart Freeze Dryer equipment has an isolation valve between the product and condenser chamber. ... Baxter is the only company that applies FTIR/freeze-dry microscopy technology in freeze-drying ...

Freeze drying of orally disintegrating tablets containing ...

Orally disintegrating tablets (ODTs) were freeze dried in blisters using the Lyostar II SMART™ Freeze Dryer Technology. ODT formulations either without non-water soluble particles (placebo) or containing large fractions (717 mg) of taste-masked naproxen sodium (NaS) granules were freeze dried. The process data revealed differences between ...

Freeze-drying process design by manometric temperature ...

Purpose: To develop a procedure based on manometric temperature measurement (MTM) and an expert system for good practices in freeze drying that will allow development of an optimized freeze-drying process during a single laboratory freeze-drying experiment. Methods: Freeze drying was performed with a FTS Dura-Stop/Dura-Top freeze dryer with the manometric …

Freeze Drying with the Help of Vacuum Technology Busch ...

Sep 02, 2021 Freeze drying is a modern extension of traditional drying methods to protect food from spoilage for longer. This process is only made possible by modern vacuum technology because freeze drying food takes place under vacuum. FrostX produces such freeze dryers with small dimensions to make them ideally suitable for bakeries and restaurants.

Use of manometric temperature measurement (MTM) and SMART ...

Sep 12, 2007 This report provides, for the first time, a summary of experiments using SMART™ Freeze Dryer technology during a 9 month testing period. A minimum ice sublimation area of about 300 cm 2 for the laboratory freeze dryer, with a chamber volume 107.5 L, was found consistent with data obtained during previous experiments with a smaller freeze dryer (52 L).

SMART Freeze Drying Lyophilizers - SP Scientific

SMART Freeze Dryer Technology (PLC) helps automate and shorten the development of the freeze drying cycle Get product information that has previously been unavailable – such as product resistance, heat flow and mass transfer Designed to minimize issues with transfer of freeze drying cycles to your production freeze dryer

World Leaders in Freeze-Dryer Technology - IPT Online

SMART technology enables the lyophilization scientist to develop an optimized freeze-drying cycle within just one or two development runs. This shortens development time by 79% or more. SMART also generates detailed process data, such as product resistance and heat flow, further sav-ing valuable scientist time. SMART’s comprehensive data ...

Optimization - LabRepCo LLC

SMART ™ and . ControLyo ™ Technology, the LyoStar offers more capability in a development freeze-dryer than any system available. Additional equipment options include a clean-room configuration, sample thief, shelf latching kits and 21 CFR Part 11 compliant software. LyoStar ™ 3 | 01. Configured with the latest innovations in freeze ...

Line of Sight Range - Freeze-Drying Experts - SP Scientific

SMART™ Freeze Dryer technologyis a primary drying optimization tool with wide industry acceptance. Patented Manometric Temperature Measurement (MTM), a pressure rise measurement technique, is used to determine cake resistance and product temperature at the ice interface amongst other parameters.

Tunable Diode Laser Absorption Spectroscopy (TDLAS ...

The SMART TDLAS-based Freeze-Dryer technology utilizes batch average water vapor mass flow rate values measured by the TDLAS sensor in conjunction with the pseudo steady-state heat and mass transfer model of freeze- drying to calculate product temperatures in real-time during freeze drying. The accuracy of

Publications Presentations PSI - Physical Sciences Inc.

The temperatures combined with a process development algorithm produced efficient freeze-drying cycles during a single lyophilization experiment. The SMART-TDLAS Freeze-Dryer Technology was used to dry placebo formulations in laboratory and pilot-scale lyophilizers, demonstrating application at multiple scales.

Use of manometric temperature measurement (MTM) and SMART ...

This report provides, for the first time, a summary of experiments using SMART Freeze Dryer technology during a 9 month testing period. A minimum ice sublimation area of …

Use of manometric temperature measurement (MTM) and SMART ...

This report provides, for the first time, a summary of experiments using SMART™ Freeze Dryer technology during a 9 month testing period. A minimum ice sublimation area of about 300 cm 2 for the laboratory freeze dryer, with a chamber volume 107.5 L, was found consistent with data obtained during previous experiments with a smaller freeze dryer (52 L).

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